Predictability effects in adult-directed and infant-directed speech: Does the listener matter?

A well-known effect in speech production is that more predictable words tend to be phonetically reduced. Recent work has suggested that predictability effects result from hardwired properties of the language production system, rather than active modulation by the talker to accommodate the listener. However, these studies investigated only minor manipulations of listener characteristics. Here, we examine predictability effects with two very different listener populations: adults and preverbal infants. Using mixed effects regressions on spontaneous speech corpora, we compare the effect of word frequency, probability in context, and previous mention on word duration in adult-directed and infant-directed speech. We find that the effects of preceding context and word frequency differ according to listener. Contrary to previous work, these results suggest that talkers do modulate the phonetic effects of predictability based on listener characteristics. To our knowledge, this study is also the first published analysis of predictability effects in infant-directed speech

Unsupervised syntactic chunking with acoustic cues: Computational models for prosodic bootstrapping

Learning to group words into phrases without supervision is a hard task for NLP systems, but infants routinely accomplish it. We hypothesize that infants use acoustic cues to prosody, which NLP systems typically ignore. To evaluate the utility of prosodic information for phrase discovery, we present an HMM-based unsupervised chunker that learns from only transcribed words and raw acoustic correlates to prosody. Unlike previous work on unsupervised parsing and chunking, we use neither gold standard part-of-speech tags nor punctuation in the input. Evaluated on the Switchboard corpus, our model outperforms several baselines that exploit either lexical or prosodic information alone, and, despite producing a flat structure, performs competitively with a state-of-the-art unsupervised lexicalized parser, with a substantial advantage in precision. Our results support the hypothesis that acoustic-prosodic cues provide useful evidence about syntactic phrases for language-learning infants.10 page(s

Talkers account for listener and channel characteristics to communicate efficiently

A well-known effect in speech production is that more predictable linguistic constructions tend to be reduced. Recent work has interpreted this effect in an information-theoretic framework, proposing that such predictability effects reflect a tendency towards communicative efficiency. However, others have argued that these effects are, in the terminology of Gould and Lewontin (1979), spandrels: incidental by-products of other processes (such as a talker-oriented tendency for low production effort). This article develops the information-theoretic framing more fully, showing that information-theoretic efficiency involves different kinds of coding operations (predictability effects), not all of which are consistent with the spandrel account. Using mixed effects regressions, we analyze word durations in several spontaneous speech corpora, comparing predictability effects between infant-directed and adult-directed speech and between speech to visible and invisible listeners. We find that talkers adjust the extent to which production varies with predictability measures according to listener characteristics, and exploit an additional visual channel to eliminate phonetic redundancy. This pattern would demand multiple independent spandrel accounts, but is unified by an adaptive account. Our results broaden the scope of existing work on predictability effects and provide further evidence that these effects are tied to communicative efficiency.17 page(s

Regulation and Dysregulation of Immunoglobulin E: A Molecular and Clinical Perspective

Background: Altered levels of Immunoglobulin E (IgE) represent a dysregulation of IgE synthesis and may be seen in a variety of immunological disorders. The object of this review is to summarize the historical and molecular aspects of IgE synthesis and the disorders associated with dysregulation of IgE production.Methods: Articles published in Medline/PubMed were searched with the keyword Immunoglobulin E and specific terms such as class switch recombination, deficiency and/or specific disease conditions (atopy, neoplasia, renal disease, myeloma, etc.). The selected papers included reviews, case reports, retrospective reviews and molecular mechanisms. Studies involving both sexes and all ages were included in the analysis.Results: Both very low and elevated levels of IgE may be seen in clinical practice. Major advancements have been made in our understanding of the molecular basis of IgE class switching including roles for T cells, cytokines and T regulatory (or Treg) cells in this process. Dysregulation of this process may result in either elevated IgE levels or IgE deficiency.Conclusion: Evaluation of a patient with elevated IgE must involve a detailed differential diagnosis and consideration of various immunological and non-immunological disorders. The use of appropriate tests will allow the correct diagnosis to be made. This can often assist in the development of tailored treatments

Control of intestinal stem cell function and proliferation by mitochondrial pyruvate metabolism.

Most differentiated cells convert glucose to pyruvate in the cytosol through glycolysis, followed by pyruvate oxidation in the mitochondria. These processes are linked by the mitochondrial pyruvate carrier (MPC), which is required for efficient mitochondrial pyruvate uptake. In contrast, proliferative cells, including many cancer and stem cells, perform glycolysis robustly but limit fractional mitochondrial pyruvate oxidation. We sought to understand the role this transition from glycolysis to pyruvate oxidation plays in stem cell maintenance and differentiation. Loss of the MPC in Lgr5-EGFP-positive stem cells, or treatment of intestinal organoids with an MPC inhibitor, increases proliferation and expands the stem cell compartment. Similarly, genetic deletion of the MPC in Drosophila intestinal stem cells also increases proliferation, whereas MPC overexpression suppresses stem cell proliferation. These data demonstrate that limiting mitochondrial pyruvate metabolism is necessary and sufficient to maintain the proliferation of intestinal stem cells

Expression of costimulatory molecules in the bovine corpus luteum

BACKGROUND: Bovine luteal parenchymal cells express class II major histocompatibility complex (MHC) molecules and stimulate class II MHC-dependent activation of T cells in vitro. The ability of a class II MHC-expressing cell type to elicit a response from T cells in vivo is also dependent on expression of costimulatory molecules by the antigen presenting cell and delivery of a costimulatory signal to the T cell. Whether bovine luteal parenchymal cells express costimulatory molecules and can deliver the costimulatory signal is currently unknown. METHODS: Bovine luteal tissue was collected during the early (day 5; day of estrus = day 0), mid (day 11–12), or late (day 18) luteal phase of the estrous cycle, and at 0, 0.5, 1, 4, 12 or 24 hours following administration of PGF2alpha to cows on day 10 of the estrous cycle. Northern analysis was used to measure CD80 or CD86 mRNA concentrations in luteal tissue samples. Mixed luteal parenchymal cell cultures and purified luteal endothelial cell cultures were prepared, and real-time RT-PCR was used to examine the presence of CD80 and CD86 mRNA in each culture type. Monoclonal antibodies to CD80 and CD86 were added to a mixed luteal parenchymal cell-T cell co-culture in vitro T cell proliferation assay to assess the functional significance of costimulatory molecules on activation of T lymphocytes by luteal parenchymal cells. RESULTS: Northern analysis revealed CD80 and CD86 mRNAs in luteal tissue, with greatest steady-state concentrations at midcycle. CD80 and CD86 mRNAs were detected in mixed luteal parenchymal cell cultures, but only slight amounts of CD80 (and not CD86) mRNA were detected in cultures of luteal endothelial cells. Luteinizing hormone, PGF2alpha and TNF-alpha were without effect on concentrations of CD80 or CD86 mRNA in mixed luteal parenchymal cells cultures. Anti-CD80 or anti-CD86 monoclonal antibodies inhibited T cell proliferation in the in vitro T cell proliferation assay. CONCLUSION: It can be concluded from this study that parenchymal cells within the bovine CL express functional costimulatory molecules that facilitate interactions between with T cells, and these components of the antigen presentation pathway are expressed maximally in the midcycle CL

Double Spin Asymmetry of Electrons from Heavy Flavor Decays in p+p Collisions at sqrt(s)=200 GeV

We report on the first measurement of double-spin asymmetry, A_LL, of electrons from the decays of hadrons containing heavy flavor in longitudinally polarized p+p collisions at sqrt(s)=200 GeV for p_T= 0.5 to 3.0 GeV/c. The asymmetry was measured at mid-rapidity (|eta|<0.35) with the PHENIX detector at the Relativistic Heavy Ion Collider. The measured asymmetries are consistent with zero within the statistical errors. We obtained a constraint for the polarized gluon distribution in the proton of |Delta g/g(log{_10}x= -1.6^+0.5_-0.4, {mu}=m_T^c)|^2 < 0.033 (1 sigma), based on a leading-order perturbative-quantum-chromodynamics model, using the measured asymmetry.Comment: 385 authors, 17 pages, 15 figures, 5 tables. Submitted to Phys. Rev. D. Plain text data tables for the points plotted in figures for this and previous PHENIX publications are (or will be) publicly available at http://www.phenix.bnl.gov/papers.htm

Upsilon (1S+2S+3S) production in d+Au and p+p collisions at sqrt(s_NN)=200 GeV and cold-nuclear matter effects

The three Upsilon states, Upsilon(1S+2S+3S), are measured in d+Au and p+p collisions at sqrt(s_NN)=200 GeV and rapidities 1.2<|y|<2.2 by the PHENIX experiment at the Relativistic Heavy-Ion Collider. Cross sections for the inclusive Upsilon(1S+2S+3S) production are obtained. The inclusive yields per binary collision for d+Au collisions relative to those in p+p collisions (R_dAu) are found to be 0.62 +/- 0.26 (stat) +/- 0.13 (syst) in the gold-going direction and 0.91 +/- 0.33 (stat) +/- 0.16 (syst) in the deuteron-going direction. The measured results are compared to a nuclear-shadowing model, EPS09 [JHEP 04, 065 (2009)], combined with a final-state breakup cross section, sigma_br, and compared to lower energy p+A results. We also compare the results to the PHENIX J/psi results [Phys. Rev. Lett. 107, 142301 (2011)]. The rapidity dependence of the observed Upsilon suppression is consistent with lower energy p+A measurements.Comment: 495 authors, 11 pages, 9 figures, 5 tables. Submitted to Phys. Rev. C. Plain text data tables for the points plotted in figures for this and previous PHENIX publications are (or will be) publicly available at http://www.phenix.bnl.gov/papers.htm

Measurement of long-range angular correlation and quadrupole anisotropy of pions and (anti)protons in central dd++Au collisions at sNN\sqrt{s_{_{NN}}}=200 GeV

We present azimuthal angular correlations between charged hadrons and energy deposited in calorimeter towers in central $d$$+$Au and minimum bias $p$$+$$p$ collisions at $\sqrt{s_{_{NN}}}=200$ GeV. The charged hadron is measured at midrapidity $|\eta|<0.35$, and the energy is measured at large rapidity ($-3.7<\eta<-3.1$, Au-going direction). An enhanced near-side angular correlation across $|\Delta\eta| >$ 2.75 is observed in $d$$+$Au collisions. Using the event plane method applied to the Au-going energy distribution, we extract the anisotropy strength $v_2$ for inclusive charged hadrons at midrapidity up to $p_T=4.5$ GeV/$c$. We also present the measurement of $v_2$ for identified $\pi^{\pm}$ and (anti)protons in central $d$$+$Au collisions, and observe a mass-ordering pattern similar to that seen in heavy ion collisions. These results are compared with viscous hydrodynamic calculations and measurements from $p$$+$Pb at $\sqrt{s_{_{NN}}}=5.02$ TeV. The magnitude of the mass-ordering in $d$$+$Au is found to be smaller than that in $p$$+$Pb collisions, which may indicate smaller radial flow in lower energy $d$$+$Au collisions.Comment: 424 authors, 8 pages, and 4 figures. v2 is version accepted for publication in Phys. Rev. Lett. Published version will be at http://www.phenix.bnl.gov/phenix/WWW/info/pp1/161/ Plain text data tables will be at http://www.phenix.bnl.gov/papers.htm